RESEARCH DESCRIPTION

Project Name: การศึกษาความสัมพันธ์ระหว่างระดับ urocortins ในเลือดกับการทำงานของหัวใจล่างด้านซ้ายของผู้ป่วยที่มีภาวะหัวใจล้มเหลว (Relationship between plasma urocortins and left ventricular function in heart failure patients.)

Researcher: Narissara Lailerd

Organization:Medicine/Physiology

Time:1 October 2006 - 30 September 2007

RESEARCHER

  1. Narissara Lailerd (Head of project)
  2. Nipon Chattipakorn (Corporate person of project)

BUDGET

  1. BioMedical Engineering Center 169,950 Baht

ABSTRACT

Heart failure and ischemic heart diseases are common cardiac syndrome in which the incidence has been shown to increase in most nations around the world.  The progress of this clinical syndrome can lead to left ventricular dysfunction including systolic and diastolic dysfunction and sudden cardiac death. Mortality rate has increased 40-50% in advanced heart failure and 15-25% in mild to moderate heart failure within one year of diagnosis. Therefore, current medical treatment focuses on the prevention of the progression of diseases.  To reach this goal, identification of the patients at the early stage of the disease is important since the late stage of heart failure has shown a poor prognosis with high mortality.  In the past decades, several cardiac markers have been shown a predictive value regarding the progression and the prognosis of myocardial infarction and heart failure patients.  These markers include NT-proBNP, cardiac troponin, hs-CRP, and creatine kinase.  However, these cardiac markers alone were unsatisfactory because these cardiac markers may affect via other pathophysiological conditions such as inflammation or other diseases.  Recently, a novel cardiovascular peptide, "Urocortins", has been emphasized its potential value as an early diagnostic marker in heart failure. It may be a novel useful tool in identifying patients with heart failure who are at increased risk for progressive ventricular dysfunction and death. However, plasma urocortins level and its correlation with left ventricular function have never been established.
Therefore, the present study is hypothesized that urocortins may be used to stratify patients undergoing heart failure in to high and low risk groups for future cardiac events. To assess this hypothesis, this study investigates the relation of plasma urocortins level and the left ventricular function evaluated by echocardiography measurement.